Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli | African swine fever virus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
35dd(G) DNA | competitive inhibition | African swine fever virus | |
dATP | using dATP as an inhibitor and dCTP as a varied substrate, the pattern of inhibition is competitive | African swine fever virus | |
additional information | Pol X is not inhibited noticeably by up to 1 mM diphosphate, at higher concentrations there is modest inhibition | African swine fever virus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | binding of Mg2+-dNTP to Pol X facilitates subsequent formation of the catalytically competent Pol X-DNA-dNTP ternary complex, Pol X prefers an ordered sequential mechanism with Mg2+-dNTP as the first substrate | African swine fever virus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
African swine fever virus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
African swine fever virus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | - |
African swine fever virus | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase X | - |
African swine fever virus |
Pol X | - |
African swine fever virus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00046 | - |
35dd(G) DNA | - |
African swine fever virus | |
0.048 | - |
dATP | - |
African swine fever virus |