Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.7 extracted from

  • Yasui, M.; Suenaga, E.; Koyama, N.; Masutani, C.; Hanaoka, F.; Gruz, P.; Shibutani, S.; Nohmi, T.; Hayashi, M.; Honma, M.
    Miscoding properties of 2-deoxyinosine, a nitric oxide-derived DNA adduct, during translesion synthesis catalyzed by human DNA polymerases (2008), J. Mol. Biol., 377, 1015-1023.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens all pols exclusively promote misincorporation of dCMP opposite a 2'-deoxyinosine lesion during translesion synthesis, isozymes pol alpha, pol eta, and pol kappaDELTAC promote preferential incorporation of 2'-deoxycytidine monophosphate , the wrong base, opposite a 2'-deoxyinosine lesion, no incorporation of 2'-deoxythymidine monophosphate, the correct base, is observed opposite the lesion ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
additional information all pols exclusively promote misincorporation of dCMP opposite a 2'-deoxyinosine lesion during translesion synthesis, isozymes pol alpha, pol eta, and pol kappaDELTAC promote preferential incorporation of 2'-deoxycytidine monophosphate , the wrong base, opposite a 2'-deoxyinosine lesion, no incorporation of 2'-deoxythymidine monophosphate, the correct base, is observed opposite the lesion Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase
-
Homo sapiens
pol alpha isozyme Homo sapiens
Pol eta isozyme Homo sapiens
pol kappaDELTAC truncated form of isozyme pol kappa Homo sapiens