Organism | UniProt | Comment | Textmining |
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Saccharolobus solfataricus | - |
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Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 | nucleotidyl-transfer reaction mechanism, intermediate structures and energy profiles, overview | Saccharolobus solfataricus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | the nucleotidyl-transfer reaction coupled with the conformational transitions in DNA polymerases is critical for maintaining the fidelity and efficiency of DNA synthesis, correct insertion of dCTP opposite 8-oxoguanine and quantum mechanics/molecular mechanics investigation of the chemical reaction in Dpo4 reveals water-dependent pathways and requirements for active site reorganization, overview | Saccharolobus solfataricus | diphosphate + DNAn+1 | - |
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additional information | simulation model of the solvated Dpo4/DNA/8-oxoG:dCTP complex, catalytic site structure, overview | Saccharolobus solfataricus | ? | - |
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Synonyms | Comment | Organism |
---|---|---|
DNA polymerase IV | - |
Saccharolobus solfataricus |
Dpo4 | - |
Saccharolobus solfataricus |
More | the enzyme belongs to the Y-family polymerases | Saccharolobus solfataricus |