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Literature summary for 2.7.7.7 extracted from
- Hydroxyurea enhances the activity of acyclovir and cidofovir against herpes simplex virus type 1 resistant strains harboring mutations in the thymidine kinase and/or the DNA polymerase genes (2008), Antiviral Res., 77, 77-80.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| D907V | mutant is less resistant to acyclovir and cidofovir than the wild type enzyme | Human alphaherpesvirus 1 |
| L778M | mutant is less resistant to acyclovir and cidofovir than the wild type enzyme | Human alphaherpesvirus 1 |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human alphaherpesvirus 1 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| deoxynucleoside triphosphate + DNAn | - |
Human alphaherpesvirus 1 | diphosphate + DNAn+1 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DNA polymerase | - |
Human alphaherpesvirus 1 |
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Release 2023.1 (January 2023)
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