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Literature summary for 2.7.7.7 extracted from

  • Pursell, Z.F.; Isoz, I.; Lundstroem, E.B.; Johansson, E.; Kunkel, T.A.
    Regulation of B family DNA polymerase fidelity by a conserved active site residue: characterization of M644W, M644L and M644F mutants of yeast DNA polymerase epsilon (2007), Nucleic Acids Res., 35, 3076-3086.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
M644F mutant enzyme has reduced fidelity resulting from strongly increased misinsertion rates Saccharomyces cerevisiae
M644L mutant enzyme synthesizes DNA with high fidelity Saccharomyces cerevisiae
M644W mutant enzyme synthesizes DNA with high fidelity Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
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-
-

Synonyms

Synonyms Comment Organism
DNA polymerase epsilon
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Saccharomyces cerevisiae