Literature summary for 2.7.7.7 extracted from

Ishimaru, C.; Kuriyama, I.; Shimazaki, N.; Koiwai, O.; Sakaguchi, K.; Kato, I.; Yoshida, H.; Mizushina, Y.
Cholesterol hemisuccinate: a selective inhibitor of family X DNA polymerases (2007), Biochem. Biophys. Res. Commun., 354, 619-625.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
cholesterol hemisuccinate	pol beta	Bos taurus
cholesterol hemisuccinate	pol beta; pol iota; pol kappa; pol lambda	Homo sapiens
cholesterol hemisuccinate	pol beta	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Synonyms

Synonyms	Comment	Organism
DNA polymerase alpha	-	Bos taurus
DNA polymerase beta	-	Rattus norvegicus
DNA polymerase delta	-	Homo sapiens
DNA polymerase epsilon	-	Homo sapiens
DNA polymerase eta	-	Homo sapiens
DNA polymerase gamma	-	Homo sapiens
DNA polymerase iota	-	Homo sapiens
DNA polymerase kappa	-	Homo sapiens
DNA polymerase lambda	-	Homo sapiens
pol beta	-	Rattus norvegicus
Pol lambda	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0029	-	pol beta	Rattus norvegicus	cholesterol hemisuccinate
0.0063	-	pol lambda	Homo sapiens	cholesterol hemisuccinate
0.0892	-	DNA polymerase delta	Homo sapiens	cholesterol hemisuccinate
0.0968	-	DNA polymerase alpha	Bos taurus	cholesterol hemisuccinate
0.12	-	DNA polymerase eta	Homo sapiens	cholesterol hemisuccinate
0.122	-	DNA polymerase ita	Homo sapiens	cholesterol hemisuccinate
0.125	-	DNA polymerase kappa	Homo sapiens	cholesterol hemisuccinate
0.131	-	DNA polymerase gamma	Homo sapiens	cholesterol hemisuccinate
0.148	-	DNA polymerase epsilon	Homo sapiens	cholesterol hemisuccinate

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Release 2023.1 (January 2023)