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Literature summary for 2.7.7.7 extracted from

  • Pavlov, Y.I.; Shcherbakova, P.V.; Kunkel, T.A.
    In vivo consequences of putative active site mutations in yeast DNA polymerases alpha, epsilon, delta, and zeta (2001), Genetics, 159, 47-64.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
Y708A mutation of pol delta, exhibits slow growth, sensitivity to hydroxyurea and strong mutator phenotype for frameshifts and base substitutions Saccharomyces cerevisiae
Y831A mutation of pol epsilon, slight sensitivity to hydroxyurea, semidominant mutator phenotype for frameshifts and base substitutions Saccharomyces cerevisiae
Y869A mutation of pol alpha, strain is viable, exhibits slow growth, sensitivity to hydroxyurea and spontaneous mutator phenotype for frameshifts and base substitutions Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Saccharomyces cerevisiae diphosphate + DNAn+1
-
?