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Literature summary for 2.7.7.7 extracted from

  • Gray, H.; Wong T.W.
    Purification and identification of subunit structure of the human mitochondrial DNA polymerase (1992), J. Biol. Chem., 267, 5835-5841.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Dideoxythymidine triphosphate 75% inhibition at 0.000001 mM Homo sapiens
additional information
-
Homo sapiens
N-ethylmaleimide 60% inhibition at 0.2 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
54000
-
1 * 54000 + 1 * 140000 Homo sapiens
140000
-
1 * 54000 + 1 * 140000 Homo sapiens
190000
-
sedimentation experiments Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Homo sapiens
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
polymerase gamma Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
5.33
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Subunits

Subunits Comment Organism
dimer 1 * 54000 + 1 * 140000 Homo sapiens