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Literature summary for 2.7.7.7 extracted from

  • Niranjanakumari, S.; Gopinathan, K.P.
    Isolation and characterization of DNA polymerase epsilon from the silk glands of Bombyx mori (1993), J. Biol. Chem., 268, 15557-15564.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
dimethyl sulfoxide inhibition of DNA polymerase epsilon, stimulation of DNA polymerase delta Bombyx mori

Inhibitors

Inhibitors Comment Organism Structure
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate inhibition of DNA polymerase alpha Bombyx mori
aphidicolin DNA polymerase epsilon, 80% inhibition at 0.002 mg/ml Bombyx mori
dimethyl sulfoxide inhibition of DNA polymerase epsilon, stimulation of DNA polymerase delta Bombyx mori
additional information no inhibition of DNA polymerase epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate Bombyx mori
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition of DNA polymerase alpha Bombyx mori

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42000
-
1 * 215000 + 1 * 42000, polymerase epsilon, denaturing PAGE Bombyx mori
215000
-
1 * 215000 + 1 * 42000, polymerase epsilon, denaturing PAGE Bombyx mori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Bombyx mori
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Bombyx mori
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DNA polymerase alpha, delta and epsilon Bombyx mori

Source Tissue

Source Tissue Comment Organism Textmining
larva
-
Bombyx mori
-
silk gland
-
Bombyx mori
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.015
-
polymerase epsilon, exonuclease activity Bombyx mori
0.031
-
polymerase epsilon, polymerase activity Bombyx mori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Bombyx mori diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn exonuclease 3'--5' activity, pol epsilon Bombyx mori diphosphate + DNAn+1
-
?
deoxynucleoside triphosphate + DNAn template specificity of DNA polymerase epsilon Bombyx mori diphosphate + DNAn+1
-
?

Subunits

Subunits Comment Organism
dimer 1 * 215000 + 1 * 42000, polymerase epsilon, denaturing PAGE Bombyx mori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
-
Bombyx mori