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Literature summary for 2.7.7.7 extracted from

  • Khan, N.N.; Reha-Krantz, L.J.; Wright, G.E.
    Analysis of inhibitors of bacteriophage T4 DNA polymerase (1994), Nucleic Acids Res., 22, 232-237.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
16-oxoaphidicholin
-
 Tequatrovirus T4
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate phage T4 enzyme inhibited with lower sensitivity than other members of the B family DNA polymerases Tequatrovirus T4
3-epiaphidicholine
-
 Tequatrovirus T4
aphidicolin phage T4 enzyme inhibited with lower sensitivity than other members of the B family DNA polymerases Tequatrovirus T4
Carbonyldiphosphonate
-
 Tequatrovirus T4
diphosphate analogs, phage T4 enzyme inhibited with lower sensitivity than other members of the B family DNA polymerases Tequatrovirus T4
additional information inhibitor analysis of bacteriophage T4 DNA polymerase Tequatrovirus T4
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate mechanism depends upon assay conditions, reversible competitive inhibition predominates Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Tequatrovirus T4
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
 Escherichia coli infected with
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Tequatrovirus T4 diphosphate + DNAn+1
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information
-
 Tequatrovirus T4
0.00054
-
 2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate pH 7.5, 30°C Tequatrovirus T4
0.00082
-
 N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate pH 7.5, 30°C Tequatrovirus T4