Literature summary for 2.7.7.65 extracted from

Cho, K.H.; Tryon, R.G.; Kim, J.H.
Screening for diguanylate cyclase (DGC) inhibitors mitigating bacterial biofilm formation (2020), Front. Chem., 8, 264 .

Inhibitors

Inhibitors	Comment	Organism
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Caulobacter vibrioides
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Clostridioides difficile
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Komagataeibacter xylinus
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Pseudomonas aeruginosa
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Salmonella enterica subsp. enterica serovar Typhimurium
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Synechocystis sp. PCC 6803
2',3'-O-[4-(dihydroxyiminio)-2,6-dinitrocyclohexa-2,5-diene-1,1-diyl]guanosine 5'-triphosphate	-	Vibrio cholerae serotype O1
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Caulobacter vibrioides
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Clostridioides difficile
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Komagataeibacter xylinus
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Pseudomonas aeruginosa
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Salmonella enterica subsp. enterica serovar Typhimurium
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Synechocystis sp. PCC 6803
2'-O-[2-(methylamino)benzoyl]guanosine 5'-(gammaS)triphosphate	-	Vibrio cholerae serotype O1
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Caulobacter vibrioides
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Clostridioides difficile
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Komagataeibacter xylinus
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Pseudomonas aeruginosa
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Salmonella enterica subsp. enterica serovar Typhimurium
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Synechocystis sp. PCC 6803
2'-O-[2-(methylamino)benzoyl]guanosine 5'-triphosphate	-	Vibrio cholerae serotype O1
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Caulobacter vibrioides
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Clostridioides difficile
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Komagataeibacter xylinus
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Pseudomonas aeruginosa
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Salmonella enterica subsp. enterica serovar Typhimurium
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Synechocystis sp. PCC 6803
2-hydroxy-5-[(E)-[4-[(pyridin-2-yl)sulfamoyl]phenyl]diazenyl]benzoic acid	-	Vibrio cholerae serotype O1
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Caulobacter vibrioides
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Clostridioides difficile
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Komagataeibacter xylinus
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Pseudomonas aeruginosa
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Salmonella enterica subsp. enterica serovar Typhimurium
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Synechocystis sp. PCC 6803
3-O-alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucuronopyranosyl soyasapogenol B 22-O-alpha-D-glucopyranoside	-	Vibrio cholerae serotype O1
3-O-alpha-L-rhamnopyronosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-gluconopyranosyl soyasapogenol B 22-o-alpha-D-glucopyranoside	potent non-competitive inhibitor in vitro, not membrane-permeable	Komagataeibacter xylinus
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Caulobacter vibrioides
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Clostridioides difficile
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Komagataeibacter xylinus
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Pseudomonas aeruginosa
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Salmonella enterica subsp. enterica serovar Typhimurium
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Synechocystis sp. PCC 6803
4-(2,5-dimethylphenoxy)-N-(4-morpholin-4-ylphenyl)butanamide	-	Vibrio cholerae serotype O1
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Caulobacter vibrioides
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Clostridioides difficile
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Komagataeibacter xylinus
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Pseudomonas aeruginosa
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Salmonella enterica subsp. enterica serovar Typhimurium
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Synechocystis sp. PCC 6803
4-chloro-3-nitro-N'-[(E)-(2,3,4-trihydroxyphenyl)methylidene]benzene-1-sulfonohydrazide	-	Vibrio cholerae serotype O1
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Caulobacter vibrioides
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Clostridioides difficile
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Komagataeibacter xylinus
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Pseudomonas aeruginosa
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Salmonella enterica subsp. enterica serovar Typhimurium
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Synechocystis sp. PCC 6803
9-(3-[4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl]propyl)-6-chloro-9H-purin-2-amine	-	Vibrio cholerae serotype O1
cyclic di-3',5'-(2'-fluoroguanylate)	-	Caulobacter vibrioides
cyclic di-3',5'-(2'-fluoroguanylate)	-	Clostridioides difficile
cyclic di-3',5'-(2'-fluoroguanylate)	-	Komagataeibacter xylinus
cyclic di-3',5'-(2'-fluoroguanylate)	-	Pseudomonas aeruginosa
cyclic di-3',5'-(2'-fluoroguanylate)	-	Salmonella enterica subsp. enterica serovar Typhimurium
cyclic di-3',5'-(2'-fluoroguanylate)	-	Synechocystis sp. PCC 6803
cyclic di-3',5'-(2'-fluoroguanylate)	-	Vibrio cholerae serotype O1
cyclic di-3',5'-inosinylic acid	-	Caulobacter vibrioides
cyclic di-3',5'-inosinylic acid	-	Clostridioides difficile
cyclic di-3',5'-inosinylic acid	-	Komagataeibacter xylinus
cyclic di-3',5'-inosinylic acid	-	Pseudomonas aeruginosa
cyclic di-3',5'-inosinylic acid	-	Salmonella enterica subsp. enterica serovar Typhimurium
cyclic di-3',5'-inosinylic acid	-	Synechocystis sp. PCC 6803
cyclic di-3',5'-inosinylic acid	-	Vibrio cholerae serotype O1
cyclo-di-GMP	-	Synechocystis sp. PCC 6803
cyclo-di-inosinylic acid	-	Synechocystis sp. PCC 6803
ebselen	-	Caulobacter vibrioides
ebselen	-	Clostridioides difficile
ebselen	-	Komagataeibacter xylinus
ebselen	-	Pseudomonas aeruginosa
ebselen	-	Salmonella enterica subsp. enterica serovar Typhimurium
ebselen	-	Synechocystis sp. PCC 6803
ebselen	-	Vibrio cholerae serotype O1
eprosartan	-	Caulobacter vibrioides
eprosartan	-	Clostridioides difficile
eprosartan	-	Komagataeibacter xylinus
eprosartan	-	Pseudomonas aeruginosa
eprosartan	-	Salmonella enterica subsp. enterica serovar Typhimurium
eprosartan	-	Synechocystis sp. PCC 6803
eprosartan	-	Vibrio cholerae serotype O1
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases; screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Caulobacter vibrioides
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Clostridioides difficile
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Komagataeibacter xylinus
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases; screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Pseudomonas aeruginosa
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Salmonella enterica subsp. enterica serovar Typhimurium
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2'(3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Synechocystis sp. PCC 6803
additional information	screenings for chemicals capable of inhibiting the c-di-GMP synthesis activity of DGCs have been performed in order to inhibit bacterial biofilm formation. 2',3'-O-(2,4,6-trinitrophenyl) (TNP)- and 2' (3')-O-(N-methylanthraniloyl) (MANT)-substituted nucleotides are potent inhibitors of guanylyl and adenylyl cyclases	Vibrio cholerae serotype O1
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134; LP3134	Caulobacter vibrioides
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134	Clostridioides difficile
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134	Komagataeibacter xylinus
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134; LP3134	Pseudomonas aeruginosa
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134	Salmonella enterica subsp. enterica serovar Typhimurium
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134	Synechocystis sp. PCC 6803
N'-((1E)-(4-ethoxy-3-[(8-oxo-1,5,6,8-tetrahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(4H)-yl)methylphenyl)methylene)]-3,4,5-trihydroxybenzohydrazide	LP3134	Vibrio cholerae serotype O1
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Caulobacter vibrioides
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Clostridioides difficile
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Komagataeibacter xylinus
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Pseudomonas aeruginosa
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Salmonella enterica subsp. enterica serovar Typhimurium
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Synechocystis sp. PCC 6803
N'-[(E)-(3,4-dihydroxyphenyl)methylidene]-4-methyl-3-nitrobenzene-1-sulfonohydrazide	-	Vibrio cholerae serotype O1
N-(4-anilinophenyl)benzamide	-	Caulobacter vibrioides
N-(4-anilinophenyl)benzamide	-	Clostridioides difficile
N-(4-anilinophenyl)benzamide	-	Komagataeibacter xylinus
N-(4-anilinophenyl)benzamide	-	Pseudomonas aeruginosa
N-(4-anilinophenyl)benzamide	-	Salmonella enterica subsp. enterica serovar Typhimurium
N-(4-anilinophenyl)benzamide	-	Synechocystis sp. PCC 6803
N-(4-anilinophenyl)benzamide	-	Vibrio cholerae serotype O1
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Caulobacter vibrioides
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Clostridioides difficile
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Komagataeibacter xylinus
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Pseudomonas aeruginosa
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Salmonella enterica subsp. enterica serovar Typhimurium
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Synechocystis sp. PCC 6803
[2- oxo-2-(2-oxopyrrolidin-1-yl)ethyl] 1,3-benzothiazole-6-carboxylate	-	Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.
2 GTP	Pseudomonas aeruginosa	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Caulobacter vibrioides	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Komagataeibacter xylinus	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Synechocystis sp. PCC 6803	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Clostridioides difficile	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Salmonella enterica subsp. enterica serovar Typhimurium	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Vibrio cholerae serotype O1	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Caulobacter vibrioides CB15N	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa ATCC 15692	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Caulobacter vibrioides NA1000	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa 1C	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa PRS 101	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa DSM 22644	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa CIP 104116	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa LMG 12228	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Vibrio cholerae serotype O1 El Tor Inaba N16961	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Pseudomonas aeruginosa JCM 14847	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	Vibrio cholerae serotype O1 ATCC 39315	-	2 diphosphate + cyclic di-3',5'-guanylate	-	?

Organism

Organism	UniProt	Comment	Textmining
Caulobacter vibrioides	A0A0H3CCZ8	Caulobacter crescentus	-
Caulobacter vibrioides	B8GZM2	-	-
Caulobacter vibrioides CB15N	A0A0H3CCZ8	Caulobacter crescentus	-
Caulobacter vibrioides NA1000	A0A0H3CCZ8	Caulobacter crescentus	-
Caulobacter vibrioides NA1000	B8GZM2	-	-
Clostridioides difficile	A0A170Y3L9	Peptoclostridium difficile or Clostridium difficile	-
Komagataeibacter xylinus	O87374	Gluconoacetobacter xylinus or Acetobacter xylinum	-
Pseudomonas aeruginosa	Q9HT84	-	-
Pseudomonas aeruginosa	Q9HXT9	-	-
Pseudomonas aeruginosa 1C	Q9HT84	-	-
Pseudomonas aeruginosa 1C	Q9HXT9	-	-
Pseudomonas aeruginosa ATCC 15692	Q9HT84	-	-
Pseudomonas aeruginosa ATCC 15692	Q9HXT9	-	-
Pseudomonas aeruginosa CIP 104116	Q9HT84	-	-
Pseudomonas aeruginosa CIP 104116	Q9HXT9	-	-
Pseudomonas aeruginosa DSM 22644	Q9HT84	-	-
Pseudomonas aeruginosa DSM 22644	Q9HXT9	-	-
Pseudomonas aeruginosa JCM 14847	Q9HT84	-	-
Pseudomonas aeruginosa JCM 14847	Q9HXT9	-	-
Pseudomonas aeruginosa LMG 12228	Q9HT84	-	-
Pseudomonas aeruginosa LMG 12228	Q9HXT9	-	-
Pseudomonas aeruginosa PRS 101	Q9HT84	-	-
Pseudomonas aeruginosa PRS 101	Q9HXT9	-	-
Salmonella enterica subsp. enterica serovar Typhimurium	Q8ZNT5	-	-
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	Q8ZNT5	-	-
Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412	Q8ZNT5	-	-
Synechocystis sp. PCC 6803	P73272	-	-
Vibrio cholerae serotype O1	Q9KKZ4	-	-
Vibrio cholerae serotype O1 ATCC 39315	Q9KKZ4	-	-
Vibrio cholerae serotype O1 El Tor Inaba N16961	Q9KKZ4	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
2 GTP	-	Pseudomonas aeruginosa	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Caulobacter vibrioides	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Komagataeibacter xylinus	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Synechocystis sp. PCC 6803	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Clostridioides difficile	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Salmonella enterica subsp. enterica serovar Typhimurium	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Vibrio cholerae serotype O1	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The DgcP of Caulobacter crescentus binds dimeric c-di-GMP at an allosteric site I-site that is characterized by the RxxD motif. Binding of cyclic-di-GMP at the I-site accounts for a strong non-competitive product inhibition, which establishes a limit on the cellular c-di-GMP concentration	Caulobacter vibrioides	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Komagataeibacter xylinus	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Synechocystis sp. PCC 6803	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Clostridioides difficile	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Salmonella enterica subsp. enterica serovar Typhimurium	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Vibrio cholerae serotype O1	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Caulobacter vibrioides CB15N	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa ATCC 15692	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa ATCC 15692	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Salmonella enterica subsp. enterica serovar Typhimurium SGSC1412	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Caulobacter vibrioides NA1000	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The DgcP of Caulobacter crescentus binds dimeric c-di-GMP at an allosteric site I-site that is characterized by the RxxD motif. Binding of cyclic-di-GMP at the I-site accounts for a strong non-competitive product inhibition, which establishes a limit on the cellular c-di-GMP concentration	Caulobacter vibrioides NA1000	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa 1C	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa 1C	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa PRS 101	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa PRS 101	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa DSM 22644	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa DSM 22644	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa CIP 104116	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa CIP 104116	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa LMG 12228	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa LMG 12228	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Vibrio cholerae serotype O1 El Tor Inaba N16961	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Vibrio cholerae serotype O1 El Tor Inaba N16961	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa JCM 14847	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Pseudomonas aeruginosa JCM 14847	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Vibrio cholerae serotype O1 ATCC 39315	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	the enzyme uses its GGDEF domain for catalysis. The GGDEF signature domain forms part of the active site A-site where GTP is bound (one molecule of GTP substrate per monomer)	Vibrio cholerae serotype O1 ATCC 39315	2 diphosphate + cyclic di-3',5'-guanylate	-	?

Synonyms

Synonyms	Comment	Organism
DGC	-	Pseudomonas aeruginosa
DGC	-	Caulobacter vibrioides
DGC	-	Komagataeibacter xylinus
DGC	-	Synechocystis sp. PCC 6803
DGC	-	Clostridioides difficile
DGC	-	Salmonella enterica subsp. enterica serovar Typhimurium
DGC	-	Vibrio cholerae serotype O1
Dgc1	-	Komagataeibacter xylinus
DgcA	-	Caulobacter vibrioides
DgcP	-	Pseudomonas aeruginosa
PleD	-	Caulobacter vibrioides
Slr1143	-	Synechocystis sp. PCC 6803
WspR	-	Pseudomonas aeruginosa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.005	-	pH and temperature not specified in the publication	Komagataeibacter xylinus	3-O-alpha-L-rhamnopyronosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-gluconopyranosyl soyasapogenol B 22-o-alpha-D-glucopyranoside
0.011	-	pH and temperature not specified in the publication	Pseudomonas aeruginosa	cyclic di-3',5'-(2'-fluoroguanylate)
0.1	-	about, pH and temperature not specified in the publication	Synechocystis sp. PCC 6803	cyclic di-3',5'-(2'-fluoroguanylate)

General Information

General Information	Comment	Organism
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Pseudomonas aeruginosa
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Caulobacter vibrioides
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Komagataeibacter xylinus
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Synechocystis sp. PCC 6803
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Clostridioides difficile
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Salmonella enterica subsp. enterica serovar Typhimurium
malfunction	enzyme inhibition by inhibitors causes inhibition of biofilm formation of the organism	Vibrio cholerae serotype O1
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain	Pseudomonas aeruginosa
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain	Caulobacter vibrioides
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain	Komagataeibacter xylinus
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain	Synechocystis sp. PCC 6803
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain	Vibrio cholerae serotype O1
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence	Pseudomonas aeruginosa
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence	Clostridioides difficile
physiological function	the primary signaling molecule promoting bacterial biofilm formation is the universal second messenger cyclic di-GMP. This dinucleotide predominantly controls the gene expression of motility, adhesins, and capsule production to coordinate biofilm formation. Cyclic di-GMP is synthesized by diguanylate cyclases (DGCs) that have a GGDEF domain and is degraded by phosphodiesterases (PDEs) containing either an EAL or an HD-GYP domain. The enzyme is important for the organism's biofilm formation ability, which plays a pivotal role in the virulence	Salmonella enterica subsp. enterica serovar Typhimurium