Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.65 extracted from

  • Biswas, S.; Chouhan, O.; Bandekar, D.
    Diguanylate cyclases in Vibrio cholerae essential regulators of lifestyle switching (2020), Front. Cell. Infect. Microbiol., 10, 582947s .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.65

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 GTP Vibrio cholerae
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio cholerae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 GTP
-
 Vibrio cholerae 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Synonyms

Synonyms Comment Organism
CdgD
-
 Vibrio cholerae
DGC
-
 Vibrio cholerae

General Information

General Information Comment Organism
malfunction the CdgD deletion mutant shows significant alteration in the biofilm formation compared to wild-type. Deletion of cdgD causes an increase in motility Vibrio cholerae
physiological function diguanylate cyclases in Vibrio cholerae are essential regulators of lifestyle switching, importance of DGCs and their product, cyclic-di-GMP, in the virulence and lifecycle of the bacteria. Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components, both proteinaceous and non-proteinaceous, the key to the regulatory control lies with the ubiquitous secondary signaling molecule, cyclic-di-GMP (c-di-GMP). Enzyme CdgD has a GGDEF domain along with a sensory PAS domain. It is a diguanylate cyclase Vibrio cholerae