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Literature summary for 2.7.7.65 extracted from

  • Biswas, S.; Chouhan, O.; Bandekar, D.
    Diguanylate cyclases in Vibrio cholerae essential regulators of lifestyle switching (2020), Front. Cell. Infect. Microbiol., 10, 582947 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.65

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 GTP Vibrio cholerae
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1 El Tor Inaba N16961
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1 Classical Ogawa 395
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1 ATCC 39541
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1 O395
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP Vibrio cholerae serotype O1 ATCC 39315
-
 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio cholerae
-
-
-
Vibrio cholerae serotype O1 A0A0H3AFM6
-
-
Vibrio cholerae serotype O1 Q9KKY5
-
-
Vibrio cholerae serotype O1 ATCC 39315 Q9KKY5
-
-
Vibrio cholerae serotype O1 ATCC 39541 A0A0H3AFM6
-
-
Vibrio cholerae serotype O1 Classical Ogawa 395 A0A0H3AFM6
-
-
Vibrio cholerae serotype O1 El Tor Inaba N16961 Q9KKY5
-
-
Vibrio cholerae serotype O1 O395 A0A0H3AFM6
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 GTP
-
 Vibrio cholerae 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 El Tor Inaba N16961 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 Classical Ogawa 395 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 ATCC 39541 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 O395 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?
2 GTP
-
 Vibrio cholerae serotype O1 ATCC 39315 2 diphosphate + cyclic di-3',5'-guanylate
-
 ?

Synonyms

Synonyms Comment Organism
CdgH
-
 Vibrio cholerae
DGC
-
 Vibrio cholerae
DGC
-
 Vibrio cholerae serotype O1
GGDEF family protein UniProt Vibrio cholerae serotype O1
VC0395_0300
-
 Vibrio cholerae serotype O1
VCA0965
-
 Vibrio cholerae serotype O1
VC_A0965
-
 Vibrio cholerae serotype O1

General Information

General Information Comment Organism
malfunction mutations at the central positions of the GGEEF sequence are detrimental to the functional activity of the enzyme. This DGC lacks the site for allosteric inhibition found in the other DGCs of Vibrio cholerae, suggesting a different mode of inhibitory control in this DGC Vibrio cholerae serotype O1
malfunction overexpression of cdgH results in a high amount of c-di-GMP accumulation in the cell Vibrio cholerae
malfunction the CdgD deletion mutant shows significant alteration in the biofilm formation compared to wild-type. Deletion of cdgD causes an increase in motility Vibrio cholerae serotype O1
additional information the structure of CdgH is solved and displays the presence of two N-terminal tandem periplasmic substrate-binding (PBPb) domains for signal recognition Vibrio cholerae
physiological function diguanylate cyclases in Vibrio cholerae are essential regulators of lifestyle switching, importance of DGCs and their product, cyclic-di-GMP, in the virulence and lifecycle of the bacteria. Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components, both proteinaceous and non-proteinaceous, the key to the regulatory control lies with the ubiquitous secondary signaling molecule, cyclic-di-GMP (c-di-GMP). Enzyme CdgD has a GGDEF domain along with a sensory PAS domain. It is a diguanylate cyclase. The enzyme does not have the conserved GGDEF motif, but has a degenerate AGDEF site. Significantly, expression of VCA0965 in Vibrio cholerae causes a 3fold reduction in flagellar-based motility. But enzyme VCA0965, despite its degenerate active site, synthesizes c-di-GMP Vibrio cholerae serotype O1
physiological function diguanylate cyclases in Vibrio cholerae are essential regulators of lifestyle switching, importance of DGCs and their product, cyclic-di-GMP, in the virulence and lifecycle of the bacteria. Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components, both proteinaceous and non-proteinaceous, the key to the regulatory control lies with the ubiquitous secondary signaling molecule, cyclic-di-GMP (c-di-GMP). Enzyme CdgH has a GGDEF domain along with a sensory PAS domain. It is a diguanylate cyclase. CdgH positively regulats the rugosity of the cel Vibrio cholerae
physiological function diguanylate cyclases in Vibrio cholerae are essential regulators of lifestyle switching, importance of DGCs and their product, cyclic-di-GMP, in the virulence and lifecycle of the bacteria. Biofilm formation in Vibrio cholerae empowers the bacteria to lead a dual lifestyle and enhances its infectivity. While the formation and dispersal of the biofilm involves multiple components, both proteinaceous and non-proteinaceous, the key to the regulatory control lies with the ubiquitous secondary signaling molecule, cyclic-di-GMP (c-di-GMP). Enzyme VC0395_0300 is a diguanylate cyclase with a GGEEF domain, it synthesizes c-di-GMP actively and has an essential role to play in the biofilm formation of Vibrio cholerae Vibrio cholerae serotype O1