Literature summary for 2.7.7.65 extracted from

Chen, Y.; Liu, S.; Liu, C.; Huang, Y.; Chi, K.; Su, T.; Zhu, D.; Peng, J.; Xia, Z.; He, J.; Xu, S.; Hu, W.; Gu, L.
Dcsbis (PA2771) from Pseudomonas aeruginosa is a highly active diguanylate cyclase with unique activity regulation (2016), Sci. Rep., 6, 29499.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
to 2.9 A resolution. A peptide loop extending from the GAF domain occupies the conserved inhibition site, thereby largely relieving the product-inhibition effect. A large hydrophobic pocket is observed in the GAF domain	Pseudomonas aeruginosa

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q9I072	-	-
Pseudomonas aeruginosa DSM 22644	Q9I072	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 GTP	-	Pseudomonas aeruginosa	2 diphosphate + cyclic di-3',5'-guanylate	-	?
2 GTP	-	Pseudomonas aeruginosa DSM 22644	2 diphosphate + cyclic di-3',5'-guanylate	-	?

Subunits

Subunits	Comment	Organism
More	full-length Dcsbis protein contains an N-terminal GAF domain and a C-terminal GGDEF domain	Pseudomonas aeruginosa

Synonyms

Synonyms	Comment	Organism
Dcsbis	-	Pseudomonas aeruginosa
PA2771	-	Pseudomonas aeruginosa

General Information

General Information	Comment	Organism
physiological function	Dcsbis tightly coordinates cell motility without markedly affecting biofilm formation and is a diguanylate cyclase with a catalytic activity much higher than those of many other diguanylate cyclases	Pseudomonas aeruginosa

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Release 2023.1 (January 2023)