Literature summary for 2.7.7.65 extracted from

Hunter, J.; Severin, G.; Koestler, B.; Waters, C.
The Vibrio cholerae diguanylate cyclase VCA0965 has an AGDEF active site and synthesizes cyclic di-GMP (2014), BMC Microbiol., 14, 22.

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Organism

Organism	UniProt	Comment	Textmining
Vibrio cholerae serotype O1	-	-	-
Vibrio cholerae serotype O1 C6706str2	-	-	-

Synonyms

Synonyms	Comment	Organism
VCA0965	-	Vibrio cholerae serotype O1

General Information

General Information	Comment	Organism
physiological function	ectopic expression of VCA0965 in ibrio. cholerae causes a 3fold reduction in flagellar-based motility. An RXXD allosteric inhibition mutant of VCA0965 strongly inhibits motility and stimulates biofilm formation. This activity is lost when the active site of VCA0965 is mutated to AGDAF, suggesting that VCA0965 synthesizes cyclic-di-GMP. Ectopic expression of VCA0965 and VCA0965 containing a mutation in its RXXD motif significantly increases the intracellular cyclic-di-GMP levels in Vibrio cholerae and Escherichia coli. Purified VCA0965 is able to synthesize cyclic-di-GMP in vitro	Vibrio cholerae serotype O1

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Release 2023.1 (January 2023)