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Literature summary for 2.7.7.60 extracted from

  • Chellapandi, P.; Prathiviraj, R.; Prisilla, A.
    Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints (2019), J. Comput. Aided Mol. Des., 33, 419-436 .
    View publication on PubMed
Search for more literature for 2.7.7.60

Cloned(Commentary)

Cloned (Comment) Organism
gene ispD, located on chromosome 1, DNA and amino acid sequence determination and analysis, phylogenetic analysis Plasmodium falciparum

Inhibitors

Inhibitors Comment Organism Structure
(3-(acetylhydroxyamino)propyl)phosphonic acid FR900098 Plasmodium falciparum
fosmidomycin 3-[formyl(hydroxy)amino]propylphosphonic acid Plasmodium falciparum
additional information inhibitor molecular docking study Plasmodium falciparum

Localization

Localization Comment Organism GeneOntology No. Textmining
apicoplast
-
 Plasmodium falciparum 20011
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate Plasmodium falciparum
-
 diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?
CTP + 2-C-methyl-D-erythritol 4-phosphate Plasmodium falciparum Tanzania (20000708)
-
 diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum A0A024WEN0
-
-
Plasmodium falciparum Tanzania (20000708) A0A024WEN0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
 Plasmodium falciparum diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
 Plasmodium falciparum Tanzania (20000708) diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
 ?
additional information substrate molecular docking study, binding site mapping and analysis Plasmodium falciparum ?
-
-
additional information substrate molecular docking study, binding site mapping and analysis Plasmodium falciparum Tanzania (20000708) ?
-
-

Synonyms

Synonyms Comment Organism
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
-
 Plasmodium falciparum
IspD
-
 Plasmodium falciparum
PlIspD
-
 Plasmodium falciparum

General Information

General Information Comment Organism
evolution structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints, e.g. Theileria annulata. Structure-based phylogeny for PlIspD homologues, constructed by using the maximum likelihood algorithm with the Dayhoff model structure and structure motifs prediction and characterization of PlIspD homologues, overview Plasmodium falciparum