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Literature summary for 2.7.7.60 extracted from

  • Kemp, L.E.; Bond, C.S.; Hunter, W.N.
    Structure of a tetragonal crystal form of Escherichia coli 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (2003), Acta Crystallogr. Sect. D, 59, 607-610.
    View publication on PubMed

Application

Application Comment Organism
drug development due to the absence of the pathway in mammals enzyme provides a potential target for new antibiotics Escherichia coli

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
25700
-
2 * 25700, crystal structure analysis Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate Escherichia coli essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + 2-C-methyl-D-erythritol 4-phosphate
-
Escherichia coli diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?
CTP + 2-C-methyl-D-erythritol 4-phosphate essential enzyme in the mevalonate-independent pathway of isoprenoid biosynthesis Escherichia coli diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol
-
?

Subunits

Subunits Comment Organism
dimer 2 * 25700, crystal structure analysis Escherichia coli