Crystallization (Comment) | Organism |
---|---|
sitting-drop vapor diffusion technique, cocrystallization of the Thermus thermophilus RNAP holoenzyme and gp39 | Thermus thermophilus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
protein gp76 | the Thermus phage protein gp76 inhibits Escherichia coli RNAP highlighting the template-DNA binding site as a target site for developing antibacterial agents | Escherichia coli | |
protein gp76 | the Thermus phage protein binds within the RNAP cleft and occupies the path of the template DNA strand at positions -11 to -4, relative to the transcription start site at +1. Thus, gp76 obstructs the formation of an open promoter complex and prevents transcription by Thermus thermophilus RNAP from most host promoters | Thermus thermophilus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Thermus thermophilus | Q5SHR6 AND Q8RQE9 AND Q8RQE8 AND Q8RQE7 | Q5SHR6: subunit alpha, Q8RQE9: subunit beta, Q8RQE8: subunit beta', Q8RQE7: subunit omega | - |
Synonyms | Comment | Organism |
---|---|---|
RNAP | - |
Escherichia coli |
RNAP | - |
Thermus thermophilus |
General Information | Comment | Organism |
---|---|---|
drug target | the template-DNA binding site is a target site for developing antibacterial agents | Escherichia coli |
drug target | the template-DNA binding site is a target site for developing antibacterial agents | Thermus thermophilus |
additional information | RNA polymerase is a major target of gene regulation | Escherichia coli |
additional information | RNA polymerase is a major target of gene regulation | Thermus thermophilus |