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Literature summary for 2.7.7.6 extracted from

  • Haurie, V.; Durrieu-Gaillard, S.; Dumay-Odelot, H.; Da Silva, D.; Rey, C.; Prochazkova, M.; Roeder, R.G.; Besser, D.; Teichmann, M.
    Two isoforms of human RNA polymerase III with specific functions in cell growth and transformation (2010), Proc. Natl. Acad. Sci. USA, 107, 4176-4181.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Cloned(Commentary)

Cloned (Comment) Organism
stable ectopic expression of subunit RPC32alpha in IMR90 fibroblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information suppression of subunit RPC32alpha expression in HeLa cells by siRNAs. Levels of p53 and lamin A/C are dramatically downregulated by ectopic RPC32alpha expression, but either unchanged (lamin A/C) or moderately increased (p53) by ectopic RPC32beta subunit expression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus isozyme Pol IIIalpha and Pol IIIbeta, primarily Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RNA polymerase III transcribes small untranslated RNAs that include tRNAs, 5S RNA, U6 RNA, and some microRNAs ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast IMR90 fibroblasts Homo sapiens
-
HeLa cell
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 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNA polymerase III transcribes small untranslated RNAs that include tRNAs, 5S RNA, U6 RNA, and some microRNAs Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
pol III
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 Homo sapiens
Pol IIIalpha
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 Homo sapiens
Pol IIIbeta
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 Homo sapiens
RNA polymerase III
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction suppression of subunit RPC32alpha expression by siRNAs impedes anchorage-independent growth of HeLa cells, whereas ectopic expression of RPC32alpha in IMR90 fibroblasts enhances cell transformation and dramatically changes the expression of several tumor-related mRNAs and that of a subset of Pol III RNAs Homo sapiens
physiological function increased Pol III transcription accompanies or causes cell transformation. RPC32beta subunit-containing isozyme Pol IIIbeta is ubiquitously expressed and essential for growth of human cells. RPC32alpha subunit-containing isozyme Pol IIIalpha is dispensable for cell survival, with expression being restricted to undifferentiated ES cells and to tumor cells. Dramatic changes in 5S RNA, U6 RNA, and 7SKRNA expression are specifically caused by ectopic expression of RPC32alpha and not due to a general deregulation of transcription Homo sapiens