Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | RNAP contains the vegetative sigma subunit sigma70 (RpoD) and/or the flagellar sigma factor sigma28 (FliA) | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | FLiZ antagonize sigmaS-dependent gene expression in Escherichia coli. FliZ is an abundant DNA-binding protein and a global regulatory protein under the control of the flagellar master regulator FlhDC. It inhibits gene expression mediated by sigmaS by recognizing operator sequences that resemble the -10 region of sigmaS-dependent promoter. FLiZ plays a pivotal role in the decision between alternative life-styles, i.e. FlhDC-controlled flagellum-based motility or pS-dependent curli fimbriae-mediated adhesion and biofilm formation. FliZ is a global repressor with a DNA sequence specificity overlapping that of sigmaScontaining RNA polymerase, mechanism, overview | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Subunits | Comment | Organism |
---|---|---|
More | RNAP contains the vegetative sigma subunit sigma70 (RpoD) and/or the flagellar sigma factor sigma28 (FliA) | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
RNAP | - |
Escherichia coli |
sigmaS-containing RNA polymerase | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme activates genes for high affinity nutrient scavenging and motility | Escherichia coli |