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Literature summary for 2.7.7.6 extracted from

  • Ponicsan, S.L.; Houel, S.; Old, W.M.; Ahn, N.G.; Goodrich, J.A.; Kugel, J.F.
    The non-coding B2 RNA binds to the DNA cleft and active-site region of RNA polymerase II (2013), J. Mol. Biol., 425, 3625-3638.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
B2 RNA the about 180-nt B2 RNA potently represses mRNA transcription by binding tightly to RNA polymerase II and assembling with it into complexes on promoter DNA, where it keeps the polymerase from properly engaging the promoter DNA. The C-terminal domain of the largest Pol II subunit is not involved. B2 RNA binds Pol II and assembles into complexes at promoters. Binding site anaylsis usig Pol II peptides, binding structure, and mechanism of transcriptional repression by B2 RNA, detailed overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the B2 family of short interspersed elements is transcribed into non-coding RNA by RNA polymerase III ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the B2 family of short interspersed elements is transcribed into non-coding RNA by RNA polymerase III Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
Pol II
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Homo sapiens
RNA polymerase II
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Homo sapiens
RNA polymerase III
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Homo sapiens