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Literature summary for 2.7.7.6 extracted from

  • Baranello, L.; Bertozzi, D.; Fogli, M.V.; Pommier, Y.; Capranico, G.
    DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus (2010), Nucleic Acids Res., 38, 159-171.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
additional information Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1alpha gene in living cells. Top1 inhibition can trigger a transcriptional stress, involving antisense transcription and increased chromatin accessibility, which is dependent on cdk activity and deregulated Pol II pausing Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
carcinoma cell
-
Homo sapiens
-
fibroblast
-
Homo sapiens
-
HCT-116 cell
-
Homo sapiens
-
JURKAT cell
-
Homo sapiens
-
MRC-5 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
Pol II
-
Homo sapiens
RNA polymerase II
-
Homo sapiens

General Information

General Information Comment Organism
malfunction DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus Homo sapiens