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Literature summary for 2.7.7.6 extracted from

  • Clemente-Blanco, A.; Mayan-Santos, M.; Schneider, D.A.; Machin, F.; Jarmuz, A.; Tschochner, H.; Aragon, L.
    Cdc14 inhibits transcription by RNA polymerase I during anaphase (2009), Nature, 458, 219-222.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Inhibitors

Inhibitors Comment Organism Structure
Cdc14 a protein phosphatase required for nucleolar segregation and mitotic exit4, inhibits RNA polymerase I, the phosphatase activity of Cdc14 is required for Pol I inhibition in vitro and in vivo involving nucleolar exclusion of Pol I subunits Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Saccharomyces cerevisiae 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Saccharomyces cerevisiae the phosphatase activity of Cdc14 is required for Pol I inhibition, transcription inhibition is necessary for complete chromosome disjunction, because rRNA transcripts block condensin binding to rDNA, and show that bypassing the role of Cdc14 in nucleolar segregation requires in vivo degradation of nascent transcripts, transcription interferes with chromosome condensation, not the reverse ?
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 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the phosphatase activity of Cdc14 is required for Pol I inhibition, transcription inhibition is necessary for complete chromosome disjunction, because rRNA transcripts block condensin binding to rDNA, and show that bypassing the role of Cdc14 in nucleolar segregation requires in vivo degradation of nascent transcripts, transcription interferes with chromosome condensation, not the reverse Saccharomyces cerevisiae ?
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 ?

Synonyms

Synonyms Comment Organism
Pol I
-
 Saccharomyces cerevisiae
RNA polymerase I
-
 Saccharomyces cerevisiae