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Literature summary for 2.7.7.6 extracted from

  • Boeing, S.; Rigault, C.; Heidemann, M.; Eick, D.; Meisterernst, M.
    RNA polymerase II C-terminal heptarepeat domain Ser-7 phosphorylation is established in a mediator-dependent fashion (2010), J. Biol. Chem., 285, 188-196.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information the RNA polymerase complex requires several transcription factors for activity, e.g. the general transcription factors, TBP, TFIIA, TFIIB, TFIIF, and TFIIE Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein RNAPII C-terminal heptarepeat domain is subject to phosphorylation, e.g. at Ser5 and Ser7, during initiation and elongation of transcription by RNA polymerase II, e.g. by cyclin-dependent kinase 7, CDK7. Phosphorylation of both Ser5 and Ser7 is fully dependent on the cofactor complex Mediator. A subform of Mediator associated with an active RNAPII is critical for preinitiation complex formation and CTD phosphorylation. Free RNAPII that is recruited to templates in the absence of Mediator is not efficiently phosphorylated by CDK7. The Mediator-RNAPII complex independently recruits TFIIB and CDK7 to core promoter regions. CDK7 phosphorylates Ser7 selectively in the context of an intact preinitiation complex, inhibition by roscovitine, molecular mechanisms, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn in vitro transcription reactions with ATP, CTP, 3'-methyl-GTP, UTP, and DNA Homo sapiens diphosphate + RNAn+1
-
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Synonyms

Synonyms Comment Organism
RNA polymerase II
-
Homo sapiens
RNAPII
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Homo sapiens