Literature summary for 2.7.7.6 extracted from

Ardehali, M.B.; Yao, J.; Adelman, K.; Fuda, N.J.; Petesch, S.J.; Webb, W.W.; Lis, J.T.
Spt6 enhances the elongation rate of RNA polymerase II in vivo (2009), EMBO J., 28, 1067-1077.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	the enzyme complex requires multiple transcription factors and protein interactions for activity, e.g. Spt6, overview	Drosophila melanogaster
Spt6	transcription factor, Pol II shows a broad requirement for essential Spt6 during different stages of development, e.g. for for maximal recruitment of Paf1 and Spt5 to transcriptionally active Hsp70. Spt6 interacts with both nucleosome structure and Pol II, it has a role in elongation, directed RNAi knock-down of Spt6 reduces the elongation rate, the Spt6-dependent effect on elongation rate persists during steady-state-induced transcription, reducing the elongation rate from about 1100 to 500 bp/min. Stimulation of Pol II elongation rate by Spt6 is not mediated through transcription factor TFIIS	Drosophila melanogaster

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
S2 cell	-	Drosophila melanogaster	-
salivary gland	-	Drosophila melanogaster	-

Synonyms

Synonyms	Comment	Organism
Pol II	-	Drosophila melanogaster
RNA polymerase II	-	Drosophila melanogaster

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Release 2023.1 (January 2023)