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Literature summary for 2.7.7.6 extracted from

  • Reiner, R.; Krasnov-Yoeli, N.; Dehtiar, Y.; Jarrous, N.
    Function and assembly of a chromatin-associated RNase P that is required for efficient transcription by RNA polymerase I (2008), PLoS ONE, 3, e4072.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Activating Compound

Activating Compound Comment Organism Structure
RNase P required for Pol I and Pol III required Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information inactivation of RNase P, by knockdown of RNase P subunits Rpp21, Rpp29 or Rpp38 by RNA interference, reduces the level of nascent transcription by Pol I, and more considerably that of Pol III, e.g. causing marked reduction in transcription of rDNA by Pol I Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus RNase P and Pol I are located at the promoter and coding region of rDNA Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Homo sapiens
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Homo sapiens diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
Pol I
-
 Homo sapiens
pol III
-
 Homo sapiens
RNA polymerase I
-
 Homo sapiens
RNA polymerase III
-
 Homo sapiens