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Literature summary for 2.7.7.6 extracted from

  • Yuan, A.H.; Gregory, B.D.; Sharp, J.S.; McCleary, K.D.; Dove, S.L.; Hochschild, A.
    Rsd family proteins make simultaneous interactions with regions 2 and 4 of the primary sigma factor (2008), Mol. Microbiol., 70, 1136-1151.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.6

Protein Variants

Protein Variants Comment Organism
additional information phenotypes of several sigma70 mutants and of diverse rsd mutants, genetic screening for isolating enhanced-function Rsd mutants, overview. Interaction of Rsd and AlgQ mutants with region 2 and 4 of sigma70, overview Pseudomonas aeruginosa
R584A site-directed mutagenesis, the RNAP holoenzyme containing this sigma70 mutant binds preferentially to promoters bearing a specifically mutated -35 element Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Pseudomonas aeruginosa bacterial anti-sigma factors typically regulate sigma factor function by restricting the access of their cognate sigma-factors to the RNA polymerase RNAP core enzyme, regulation of RNAP holoenzyme, Esigma70, involving Rsd and the Rsd orthologue AlgQ, a global regulator of gene expression in Pseudomonas aeruginosa, which simultaneously interact with conserved region 2 and region 4 of sigma70 mediated by separate surfaces of Rsd, interaction with mutants of Rsd and AlgQ, mechanism, detailed overview. Rsd can strongly regulate the production of the Pseudomonas aeruginosa virulence factor pyocyanin in a manner that depends on their abilities to interact with sigma70 region 2 ?
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information bacterial anti-sigma factors typically regulate sigma factor function by restricting the access of their cognate sigma-factors to the RNA polymerase RNAP core enzyme, regulation of RNAP holoenzyme, Esigma70, involving Rsd and the Rsd orthologue AlgQ, a global regulator of gene expression in Pseudomonas aeruginosa, which simultaneously interact with conserved region 2 and region 4 of sigma70 mediated by separate surfaces of Rsd, interaction with mutants of Rsd and AlgQ, mechanism, detailed overview. Rsd can strongly regulate the production of the Pseudomonas aeruginosa virulence factor pyocyanin in a manner that depends on their abilities to interact with sigma70 region 2 Pseudomonas aeruginosa ?
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 ?

Synonyms

Synonyms Comment Organism
RNA polymerase core enzyme
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 Pseudomonas aeruginosa
RNAP core enzyme
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 Pseudomonas aeruginosa