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Literature summary for 2.7.7.6 extracted from

  • Skoblov, A.Y.; Sosunov, V.V.; Victorova, L.S.; Skoblov, Y.S.; Kukhanova, M.K.
    Substrate properties of dinucleoside 5',5''-oligophosphates in the reactions catalyzed by HIV reverse transcriptase, E. coli DNA polymerase I, and E. coli RNA polymerase (2005), Russ. J. Bioorg. Chem., 31, 48-57.
No PubMed abstract available
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Inhibitors

Inhibitors Comment Organism Structure
d(Ap4C) d(Ap4T), d(Ap4C) and d(Ap4G) inhibit the incorporation of dATP into DNA less effectively than d(Ap4T), d(Tp4T) and d(Tp4C) the dTTP incorporation Escherichia coli
d(Ap4G) d(Ap4T), d(Ap4C) and d(Ap4G) inhibit the incorporation of dATP into DNA less effectively than d(Ap4T), d(Tp4T) and d(Tp4C) the dTTP incorporation Escherichia coli
d(Ap4T) d(Ap4T), d(Ap4C) and d(Ap4G) inhibit the incorporation of dATP into DNA less effectively than d(Ap4T), d(Tp4T) and d(Tp4C) the dTTP incorporation Escherichia coli
d(Tp4C) d(Ap4T), d(Ap4C) and d(Ap4G) inhibit the incorporation of dATP into DNA less effectively than d(Ap4T), d(Tp4T) and d(Tp4C) the dTTP incorporation Escherichia coli
d(Tp4T) d(Ap4T), d(Ap4C) and d(Ap4G) inhibit the incorporation of dATP into DNA less effectively than d(Ap4T), d(Tp4T) and d(Tp4C) the dTTP incorporation Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0004
-
 dTTP
-
 Escherichia coli
0.00072
-
 d(Tp4T)
-
 Escherichia coli
0.00174
-
 d(Tp4G)
-
 Escherichia coli
0.00211
-
 d(Ap4T)
-
 Escherichia coli
0.00222
-
 d(Tp4C)
-
 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
d(Ap4T) + RNAn primer elongation Escherichia coli ?
-
 ?
d(TP4C) + RNAn primer elongation Escherichia coli ?
-
 ?
d(Tp4G) + RNAn primer elongation Escherichia coli ?
-
 ?
d(Tp4T) + RNAn primer elongation Escherichia coli ?
-
 ?
dTTP + RNAn primer elongation Escherichia coli ?
-
 ?
additional information dinucleoside teraphosphates are more potent substrates than dinucleoside triphosphates and dinucleoside pentaphosphates Escherichia coli ?
-
 ?