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Literature summary for 2.7.7.59 extracted from

  • Engleman, E.G.; Francis, S.H.
    Cascade control of E. coli glutamine synthetase. II. Metabolite regulation of the enzymes in the cascade (1978), Arch. Biochem. Biophys., 191, 602-612.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
glutamine 5 mM, no effect at pH 8.6 Escherichia coli
glutamine pH 7.6, enhances uridylyl removing activity at 0.5 mM Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
3-phosphoglycerate inhibits uridylyl removing activity Escherichia coli
acetyl-CoA inhibits uridylyl removing activity Escherichia coli
ADP inhibits uridylyl removing activity Escherichia coli
AMP inhibits uridylyl removing activity Escherichia coli
ATP inhibits uridylyl removing activity Escherichia coli
CDP inhibits uridylyl removing activity Escherichia coli
CDP-glucose inhibits uridylyl removing activity Escherichia coli
CMP inhibits uridylyl removing activity Escherichia coli
CoA inhibits uridylyl removing activity Escherichia coli
CTP inhibits uridylyl removing activity Escherichia coli
D-fructose 1,6-diphosphate inhibits uridylyl removing activity Escherichia coli
dCMP inhibits uridylyl removing activity Escherichia coli
dUMP inhibits uridylyl removing activity Escherichia coli
GDP inhibits uridylyl removing activity Escherichia coli
GMP inhibits uridylyl removing activity Escherichia coli
GTP inhibits uridylyl removing activity Escherichia coli
IDP inhibits uridylyl removing activity Escherichia coli
IMP inhibits uridylyl removing activity Escherichia coli
ITP inhibits uridylyl removing activity Escherichia coli
NAD+ inhibits uridylyl removing activity Escherichia coli
NADH inhibits uridylyl removing activity Escherichia coli
NADP+ inhibits uridylyl removing activity Escherichia coli
NADPH inhibits uridylyl removing activity Escherichia coli
phosphoenolpyruvate inhibits uridylyl removing activity Escherichia coli
TDP inhibits uridylyl removing activity Escherichia coli
TMP inhibits uridylyl removing activity Escherichia coli
TTP inhibits uridylyl removing activity Escherichia coli
UDP inhibits uridylyl removing activity Escherichia coli
UDP-glucose inhibits uridylyl removing activity Escherichia coli
UMP inhibits uridylyl removing activity Escherichia coli
UTP inhibits uridylyl removing activity Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UTP + [protein-PII] Escherichia coli the enzyme is involved in the cascade control of glutamine synthetase diphosphate + uridylyl-[protein-PII]
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UTP + [protein-PII]
-
 Escherichia coli diphosphate + uridylyl-[protein-PII]
-
 r
UTP + [protein-PII] the enzyme is involved in the cascade control of glutamine synthetase Escherichia coli diphosphate + uridylyl-[protein-PII]
-
 r