Protein Variants | Comment | Organism |
---|---|---|
A149Del | an Ala149 deletion mutant displays substrate specificity for diadenosine 5',5'''-P1,P5-pentaphosphate and is inactive on Ap4A and other substrates utilized by the wild-type enzyme | Mycobacterium tuberculosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WMK9 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WMK9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
P1,P3-bis(5'-adenosyl) triphosphate + phosphate | wild-type, 19% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 29%, respectively | Mycobacterium tuberculosis | 2 ADP | - |
? | |
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate | - |
Mycobacterium tuberculosis | ADP + ATP | - |
? | |
P1,P4-bis(5'-adenosyl)tetraphosphate + phosphate | - |
Mycobacterium tuberculosis H37Rv | ADP + ATP | - |
? | |
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate | wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively | Mycobacterium tuberculosis | GTP + GDP | - |
? | |
P1,P4-bis(5'-guanosyl) tetraphosphate + phosphate | wild-type, 107% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 53%, respectively | Mycobacterium tuberculosis H37Rv | GTP + GDP | - |
? | |
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate | wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively | Mycobacterium tuberculosis | ? | - |
? | |
P1,P5-bis(5'-adenosyl)pentaphosphate + phosphate | wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 290%, respectively | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
P1,P5-bis(5'-guanosyl)pentaphosphate + phosphate | wild-type, 106% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 95%, respectively | Mycobacterium tuberculosis | ? | - |
? | |
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate | wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively | Mycobacterium tuberculosis | ? | - |
? | |
P1,P6-bis(5'-adenosyl)hexaphosphate + phosphate | wild-type, 25% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, very poor substrate for mutant A149Del, respectively | Mycobacterium tuberculosis H37Rv | ? | - |
? | |
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate | wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively | Mycobacterium tuberculosis | ATP + GDP | - |
? | |
P1-(5'-adenosyl)P4-(5'-guanosyl) tetraphosphate + phosphate | wild-type, 100% of the rate with P1,P4-bis(5'-adenosyl) tetraphosphate, mutant A149Del 67%, respectively | Mycobacterium tuberculosis H37Rv | ATP + GDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP-4-A phosphorylase | - |
Mycobacterium tuberculosis |
Ap4A phosphorylase | - |
Mycobacterium tuberculosis |