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Literature summary for 2.7.7.53 extracted from

  • Brevet, A.; Coste, H.; Fromant, M.; Plateau, P.; Blanquet, S.
    Yeast diadenosine 5,5-P1,P4-tetraphosphate alpha,beta-phosphorylase behaves as a dinucleoside tetraphosphate synthetase (1987), Biochemistry, 26, 4763-4768.
    View publication on PubMed
Search for more literature for 2.7.7.53

Inhibitors

Inhibitors Comment Organism Structure
EDTA
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.31
-
 ADP pH 5.9, 37°C Saccharomyces cerevisiae
5.7
-
 ATP pH 5.9, 37°C Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ as good as Mn2+ Saccharomyces cerevisiae
Co2+ slight activation of P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis Saccharomyces cerevisiae
Mg2+ less effective than Mn2+ or Ca2+ Saccharomyces cerevisiae
Mg2+ activation, P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis Saccharomyces cerevisiae
Mn2+ requirement, Ap4A-synthesis Saccharomyces cerevisiae
additional information no activation by Ni2+ Saccharomyces cerevisiae
additional information Cu2+ Saccharomyces cerevisiae
Zn2+ slight activation of P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate Saccharomyces cerevisiae involved in catabolism of dinucleoside polyphosphates ?
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + ATP
-
 Saccharomyces cerevisiae P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
 r
NTP + N'DP asymmetric catalytic site: synthesis of Ap4G or Ap4C is much faster from ATP plus CDP or GDP than from CTP or GTP plus ADP Saccharomyces cerevisiae P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate N is A or G, N' is A, C, G, U or dA ?
NTP + N'DP N is A or G, not C, U or dA, and N' is A, C, G, U or dA Saccharomyces cerevisiae P1,P4-bis(5'-nucleosyl) tetraphosphate' + phosphate N is A or G, N' is A, C, G, U or dA ?
P1(5'-adenosyl)-P4(5'-cytosyl) tetraphosphate + phosphate
-
 Saccharomyces cerevisiae CDP + ATP not CTP + ADP ?
P1(5'-adenosyl)-P4(5'-guanosyl) tetraphosphate + phosphate
-
 Saccharomyces cerevisiae GDP + ATP
-
 r
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate
-
 Saccharomyces cerevisiae ADP + ATP
-
 ?
P1,P4-bis(5'-adenosyl) tetraphosphate + phosphate involved in catabolism of dinucleoside polyphosphates Saccharomyces cerevisiae ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.9
-
 P1,P4-bis(5'-adenosyl) tetraphosphate-synthesis Saccharomyces cerevisiae
8
-
 P1,P4-bis(5'-adenosyl) tetraphosphate-phosphorolysis Saccharomyces cerevisiae