Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.7.7.52 extracted from

  • Heo, I.; Ha, M.; Lim, J.; Yoon, M.; Park, J.; Kwon, S.; Chang, H.; Kim, V.
    Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs (2012), Cell, 151, 521-532.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in HEK-293 cell Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q5TAX3 isoform Zcchc11, TUT4
-
Homo sapiens Q5VYS8 isoform Zcchc6, TUT7
-

General Information

General Information Comment Organism
physiological function isoforms TUT7/ZCCHC6, TUT4/ZCCHC11, and TUT2/PAPD4/GLD2 are the terminal uridylyltransferases responsible for pre-miRNA mono-uridylation. The terminal uridylyl transferases act specifically on dsRNAs with a 1 nucleotide 3' overhang, thereby creating a 2 nucleotide 3' overhang. Depletion of terminal uridylyl transferases reduces let-7 microRNA levels and disrupts let-7 function. Although the let-7 suppressor, Lin28, induces inhibitory oligo-uridylation in embryonic stem cells, mono-uridylation occurs in somatic cells lacking Lin28 to promote let-7 biogenesis Homo sapiens