Literature summary for 2.7.7.49 extracted from

Yasuno, T.; Ohe, T.; Takahashi, K.; Nakamura, S.; Mashino, T.
The human immunodeficiency virus-reverse transcriptase inhibition activity of novel pyridine/pyridinium-type fullerene derivatives (2015), Bioorg. Med. Chem. Lett., 25, 3226-3229.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-[11-(ethoxycarbonyl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylen-9-yl]-1-methylpyridinium	pyridinium fullerene derivative, 50% cytotoxicity above 0.05 mM	Human Immunodeficiency Virus
9-(pyridin-3-yl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylene-11-carboxylic acid	pyridine fullerene derivative, 50% cytotoxicity above 0.05 mM	Human Immunodeficiency Virus

Organism

Organism	UniProt	Comment	Textmining
Human Immunodeficiency Virus	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00008	-	pH not specified in the publication, temperature not specified in the publication	Human Immunodeficiency Virus	9-(pyridin-3-yl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylene-11-carboxylic acid
0.00094	-	pH not specified in the publication, temperature not specified in the publication	Human Immunodeficiency Virus	3-[11-(ethoxycarbonyl)-1,7,9,10,11,12-hexahydro-3,2-(metheno)-10-azaazuleno[1',8',7',6':3,4,5]cyclopenta[6,7]fluoreno[2,1,9,8-fghij]benzo[cd]cyclopenta[mno]acephenanthrylen-9-yl]-1-methylpyridinium

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Release 2023.1 (January 2023)