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Literature summary for 2.7.7.49 extracted from

  • Kirmizialtin, S.; Nguyen, V.; Johnson, K.; Elber, R.
    How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations (2012), Structure, 20, 618-627.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of binding of TTP and dATP to the enzyme-DNA complex, the kinetics of mismatch dATP binding are complexoverview Human immunodeficiency virus 1

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ two catalytic Mg2+ ions Human immunodeficiency virus 1

Organism

Organism UniProt Comment Textmining
Human immunodeficiency virus 1
-
-
-

Subunits

Subunits Comment Organism
More subunit p66 structure model with bound dNTP substrate and two catalytic Mg2+ ions, overview Human immunodeficiency virus 1

Synonyms

Synonyms Comment Organism
HIV-reverse transcriptase
-
Human immunodeficiency virus 1
HIV-RT
-
Human immunodeficiency virus 1

General Information

General Information Comment Organism
additional information active site structure, and structures of open, transition, and closed conformations along the enzyme reaction and specificity, molecular modeling, calculation, and molecular dynamics simulations, modeling of the p66 subunit of HIV-reverse transcriptase enzyme shown in open and closed conformations, overview Human immunodeficiency virus 1