Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-amino-5-chlorophenyl)(2-chlorophenyl)methanone | - |
Human immunodeficiency virus 1 | |
(2-amino-5-chlorophenyl)(2-fluorophenyl)methanone | - |
Human immunodeficiency virus 1 | |
(2-amino-5-chlorophenyl)(phenyl)methanone | - |
Human immunodeficiency virus 1 | |
(4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
2,4,6-trichloroquinoline | - |
Human immunodeficiency virus 1 | |
3-(3-methylbut-2-en-1-yl)-4-[(3-methylbut-2-en-1-yl)oxy]quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
3-([3-bromo-2-oxo-5-[(pyridin-3-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile | - |
Human immunodeficiency virus 1 | |
4-chloroaniline | - |
Human immunodeficiency virus 1 | |
4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-1-(2,6-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-(2-fluorophenyl)quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-(phenylsulfanyl)quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-(phenylsulfinyl)quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-(phenylsulfonyl)quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-phenoxyquinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-phenylquinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-[(3,5-dimethylphenyl)sulfinyl]quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]quinolin-2(1H)-one | - |
Human immunodeficiency virus 1 | |
efavirenz | - |
Human immunodeficiency virus 1 | |
additional information | synthesis and inhibitory activities of quinolin-2-one alkaloid derivatives against HIV-1 reverse transcriptase, molecular docking study, overview | Human immunodeficiency virus 1 | |
N-(4-chlorophenyl)acetamide | - |
Human immunodeficiency virus 1 | |
propan-2-yl 7-methoxy-2-[(methylsulfanyl)methyl]-3-thioxo-3,4-dihydroquinoxaline-1(2H)-carboxylate | - |
Human immunodeficiency virus 1 |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human immunodeficiency virus 1 | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
HIV-1 reverse transcriptase | - |
Human immunodeficiency virus 1 |
HIV-1 RT | - |
Human immunodeficiency virus 1 |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00015 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one | |
0.00021 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one | |
0.0026 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-[(3,5-dimethylphenyl)sulfinyl]quinolin-2(1H)-one | |
0.003 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-phenoxyquinolin-2(1H)-one | |
0.0056 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-(phenylsulfanyl)quinolin-2(1H)-one | |
0.0089 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-(phenylsulfinyl)quinolin-2(1H)-one | |
0.01 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]quinolin-2(1H)-one | |
0.018 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one | |
0.049 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-(phenylsulfonyl)quinolin-2(1H)-one | |
0.1 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 3-([3-bromo-2-oxo-5-[(pyridin-3-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile | |
0.1 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-phenylquinolin-2(1H)-one | |
0.1 | - |
pH and temperature not specified in the publication | Human immunodeficiency virus 1 | 6-chloro-4-(2-fluorophenyl)quinolin-2(1H)-one |