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Literature summary for 2.7.7.49 extracted from

  • Bedard, K.M.; Underbrink, M.P.; Howie, H.L.; Galloway, D.A.
    The E6 oncoproteins from human betapapillomaviruses differentially activate telomerase through an E6AP-dependent mechanism and prolong the lifespan of primary keratinocytes (2008), J. Virol., 82, 3894-3902.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
betapapillomavirus E6 protein 16E6 activates telomerase, NFX1-91 protein is important for telomerase activation by betapapillomavirus E6 protein 16E6 Homo sapiens
betapapillomavirus E6 protein 38E6 activates telomerase Homo sapiens
betapapillomavirus E6 protein E6AP important for telomerase activation by betapapillomavirus E6 protein 16E6 Homo sapiens
additional information beta-E6 proteins 5E6, 8E6, 20E6, and 22E6, exhibit low or background levels of telomerase activity Homo sapiens
NFX-91 complex formation between betapapillomavirus E6 proteins E6, E6AP, and NFX1-91 is a critical step in mediating telomerase activation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HFK cell
-
 Homo sapiens
-
keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Homo sapiens diphosphate + DNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
telomerase
-
 Homo sapiens