Literature summary for 2.7.7.49 extracted from

Bibillo, A.; Lener, D.; Tewari, A.; Le Grice, S.F.
Interaction of the Ty3 reverse transcriptase thumb subdomain with template-primer (2005), J. Biol. Chem., 280, 30282-30290.

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Protein Variants

Protein Variants	Comment	Organism
F292A	slight diminuation in DNA-dependent DNA synthesis (under conditions allowing multiple rounds of synthesis). Significant reduction in polymerase activity in presence of heparin	Saccharomyces cerevisiae
F292Y	severly impaired Rnase H activity	Saccharomyces cerevisiae
G294A	mutation results in enhanced pausing at multiple positions of the DNA template in DNA-dependent DNA synthesis (under conditions allowing multiple rounds of synthesis). Significant reduction in polymerase activity in presence of heparin	Saccharomyces cerevisiae
Y298A	slight diminuation in DNA-dependent DNA synthesis (under conditions allowing multiple rounds of synthesis). Significant reduction in polymerase activity in presence of heparin	Saccharomyces cerevisiae
Y298W	significant reduction in polymerase activity in presence of heparin	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	long terminal repeat-containing retrotransposon Ty3	-

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Release 2023.1 (January 2023)