Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dengue virus type 2 | - |
- |
- |
Dengue virus type 3 | - |
- |
- |
Dengue virus type 4 | - |
- |
- |
dengue virus type I | - |
- |
- |
Japanese encephalitis virus | - |
- |
- |
West Nile virus | - |
- |
- |
Yellow fever virus | - |
- |
- |
Zika virus | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Yellow fever virus |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | West Nile virus |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Japanese encephalitis virus |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Dengue virus type 2 |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Dengue virus type 4 |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Zika virus |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | Dengue virus type 3 |
NS5 | consists of a C-terminal RNA-dependent RNA polymerase domain and an N-terminal methyltransferase domain | dengue virus type I |
RDRP | - |
Yellow fever virus |
RDRP | - |
West Nile virus |
RDRP | - |
Japanese encephalitis virus |
RDRP | - |
Dengue virus type 2 |
RDRP | - |
Dengue virus type 4 |
RDRP | - |
Zika virus |
RDRP | - |
Dengue virus type 3 |
RDRP | - |
dengue virus type I |
RNA-dependent RNA polymerase | - |
Yellow fever virus |
RNA-dependent RNA polymerase | - |
West Nile virus |
RNA-dependent RNA polymerase | - |
Japanese encephalitis virus |
RNA-dependent RNA polymerase | - |
Dengue virus type 2 |
RNA-dependent RNA polymerase | - |
Dengue virus type 4 |
RNA-dependent RNA polymerase | - |
Zika virus |
RNA-dependent RNA polymerase | - |
Dengue virus type 3 |
RNA-dependent RNA polymerase | - |
dengue virus type I |
General Information | Comment | Organism |
---|---|---|
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | Yellow fever virus |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | West Nile virus |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | Japanese encephalitis virus |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | Dengue virus type 2 |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | Zika virus |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | Dengue virus type 3 |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to efficient genomic RNA replication | dengue virus type I |
physiological function | Flavivirus replication occurs on the ER and is regulated by many mechanisms and factors. NS5, which consists of a C-terminal RNA-dependent RNA polymerase (RdRp) domain and an N-terminal methyltransferase domain, plays a pivotal role in genome replication and capping. The C-terminal RdRp domain acts as the polymerase for RNA synthesis and cooperates with diverse viral proteins to facilitate productive RNA proliferation within the replication complex. RdRp recognizes the initiation site of the genome via an RdRp-UTR interaction, the interaction between RdRp and NS3 promotes NTPase and helicase activity, and the interaction between the RdRp and the MTase is involved in new RNA synthesis. The RdRp is indispensable for flavivirus replication because of not only its own polymerase activity, but also its interactions with other viral proteins and RNAs, which leads to ex0ecient genomic RNA replication | Dengue virus type 4 |