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Literature summary for 2.7.7.48 extracted from

  • Yin, W.; Mao, C.; Luan, X.; Shen, D.D.; Shen, Q.; Su, H.; Wang, X.; Zhou, F.; Zhao, W.; Gao, M.; Chang, S.; Xie, Y.C.; Tian, G.; Jiang, H.W.; Tao, S.C.; Shen, J.; Jiang, Y.; Jiang, H.; Xu, Y.; Zhang, S.; Zhang, Y.; Xu, H.E.
    Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir (2020), Science, 368, 1499-1504 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
remdesivir cryo-electron microscopy structure of the SARS-CoV-2 RNA-dependent RNA polymerase, both in the apo form at 2.8 A resolution and in complex with a 50-base template-primer RNA and remdesivir at 2.5 A resolution. The complex structure reveals that the partial double-stranded RNA template is inserted into the central channel of the RNA-dependent RNA polymerase, where remdesivir is covalently incorporated into the primer strand at the first replicated base pair, and terminates chain elongation Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
-
diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RDRP
-
Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
-
Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
drug target cryo-electron microscopy structure of the SARS-CoV-2 RNA-dependent RNA polymerase provides insights into the mechanism of viral RNA replication and a rational template for drug design to combat the viral infection Severe acute respiratory syndrome coronavirus 2