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Literature summary for 2.7.7.48 extracted from
- Effects of mutations on active site conformation and dynamics of RNA-dependent RNA polymerase from Coxsackievirus B3 (2017), J. Mol. Graph. Model., 77, 330-337 .
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| F364A | the hydrophobic mutation leads to conformations with closed active site | Coxsackievirus B3 |
| F364W | the mutant enzym has no preference between the open and closed active sites, similar to wild-type enzyme | Coxsackievirus B3 |
| F364Y | mutation results in structure with open active site | Coxsackievirus B3 |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | Coxsackievirus B3 | - |
diphosphate + RNAn+1 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Coxsackievirus B3 | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | - |
Coxsackievirus B3 | diphosphate + RNAn+1 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3Dpol | - |
Coxsackievirus B3 |
| RNA-dependent RNA polymerase | - |
Coxsackievirus B3 |
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Release 2023.1 (January 2023)
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