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Literature summary for 2.7.7.48 extracted from

  • Pokhrel, R.; Chapagain, P.; Siltberg-Liberles, J.
    Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2 (2020), J. Med. Microbiol., 69, 864-873 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
quinupristin virtual screen identifies several drugs predicted to bind in the conserved RNA tunnel. Quinupristin is expected to bind across the RNA tunnel, blocking access from both sides and suggesting that it has the potential to arrest viral replication by preventing viral RNA synthesis. Quinupristin is an antibiotic that has been in clinical use for two decades and causes relatively minor side effects Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
RDRP
-
 Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
-
 Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
drug target RNA-dependent RNA polymerase inhibitors are prospective therapeutics against SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2
physiological function RNA-dependent RNA polymerase is a critical enzyme for coronavirus replication Severe acute respiratory syndrome coronavirus 2