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Literature summary for 2.7.7.48 extracted from

  • Huang, J.; Song, W.; Huang, H.; Sun, Q.
    Pharmacological therapeutics targeting RNA-dependent RNA polymerase, proteinase and spike protein from mechanistic studies to clinical trials for COVID-19 (2020), J. Clin. Med., 9, 1131 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
nsp12
-
 Severe acute respiratory syndrome coronavirus 2
RDRP
-
 Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
-
 Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
drug target systemic discussion of the pharmacological therapeutics targeting RNA-dependent RNA polymerase (RdRp) Severe acute respiratory syndrome coronavirus 2
physiological function essential enzyme of the coronaviral replication/transcription machinery. It catalyzes the synthesis of coronavirus RNA Severe acute respiratory syndrome coronavirus 2