Literature summary for 2.7.7.48 extracted from

Mittal, L.; Kumari, A.; Suri, C.; Bhattacharya, S.; Asthana, S.
Insights into structural dynamics of allosteric binding sites in HCV RNA-dependent RNA polymerase (2020), J. Biomol. Struct. Dyn., 38, 1612-1625 .

Search for more literature for 2.7.7.48

Inhibitors

Inhibitors	Comment	Organism	Structure
anthranilic acid	-	Hepacivirus C
benzimidazole	-	Hepacivirus C
cyclopropylindolobenzazepine inhibitors	-	Hepacivirus C
dihydropyranone inhibitor	binding of non-nucleoside inhibitors induces significant fluctuations at the atomic level which are critical for enzymatic activity, with minimalglobal structural alterations. Residue-wise mapping of interactions of non-nucleoside inhibitors at different sites exhibits some conserved interaction patterns of key amino acids and water molecules	Hepacivirus C
indole	-	Hepacivirus C
indole diamide inhibitors	-	Hepacivirus C
indole-N-acetamide inhibitors	-	Hepacivirus C
indolo-benzoxazocine inhibitors	-	Hepacivirus C
Isoquinoline	-	Hepacivirus C
phenylalanine	binding of non-nucleoside inhibitors induces significant fluctuations at the atomic level which are critical for enzymatic activity, with minimalglobal structural alterations. Residue-wise mapping of interactions of non-nucleoside inhibitors at different sites exhibits some conserved interaction patterns of key amino acids and water molecules	Hepacivirus C
tetracyclic indole inhibitors	-	Hepacivirus C
thiazolone inhibitors	-	Hepacivirus C
thiophene	binding of non-nucleoside inhibitors induces significant fluctuations at the atomic level which are critical for enzymatic activity, with minimalglobal structural alterations. Residue-wise mapping of interactions of non-nucleoside inhibitors at different sites exhibits some conserved interaction patterns of key amino acids and water molecules	Hepacivirus C

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
nucleoside triphosphate + RNAn	Hepacivirus C	-	diphosphate + RNAn+1	-	?

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	O92972	genome polyprotein	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
RDRP	-	Hepacivirus C
RNA-dependent RNA polymerase	-	Hepacivirus C

General Information

General Information	Comment	Organism
drug target	inhibition of the viral RNA-dependent RNA polymerase (RdRp) to resolve chronic infection is a useful therapeutic strategy against Hepatitis C virus	Hepacivirus C

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Release 2023.1 (January 2023)