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Literature summary for 2.7.7.48 extracted from

  • Ao, S.; Han, D.; Sun, L.; Wu, Y.; Liu, S.; Huang, Y.
    Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening (2020), Front. Genet., 11, 581668 .
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA. Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening diphosphate + RNAn+1
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Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA. Identification of potential key agents for targeting RNA-dependent RNA polymerase of SARS-CoV-2 by integrated analysis and virtual drug screening Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
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 ?

Synonyms

Synonyms Comment Organism
RDRP
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 Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
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 Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
drug target target for antiviral drugs Severe acute respiratory syndrome coronavirus 2
physiological function key enzyme responsible for the SARS-CoV-2 replication process, catalyzes the synthesis of complementary minus strand RNA and genomic plus strand RNA Severe acute respiratory syndrome coronavirus 2