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Literature summary for 2.7.7.48 extracted from

  • Mouffouk, C.; Mouffouk, S.; Mouffouk, S.; Hambaba, L.; Haba, H.
    Flavonols as potential antiviral drugs targeting SARS-CoV-2 proteases (3CLpro and PLpro), spike protein, RNA-dependent RNA polymerase (RdRp) and angiotensin-converting enzyme II receptor (ACE2) (2020), Eur. J. Pharmacol., 891, 173759 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
nsp7 the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors Severe acute respiratory syndrome coronavirus 2
nsp8 the nsp12 (RdRp) catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors Severe acute respiratory syndrome coronavirus 2

Inhibitors

Inhibitors Comment Organism Structure
afzelin strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
Astragalin strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
biorobin strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
fisetin high affinities with the RNA-polymerase active site Severe acute respiratory syndrome coronavirus 2
kaempferol strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
Myricitrin strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
quercetin high affinities with the RNA-polymerase active site; strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
quercetin-3'-O-glucuronide better binding affinities than quercetin Severe acute respiratory syndrome coronavirus 2
quercetin-3'-O-sulfate better binding affinities than quercetin Severe acute respiratory syndrome coronavirus 2
quercetin-3-O-glucoside strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2
quercetin-3-O-glucuronide better binding affinities than quercetin Severe acute respiratory syndrome coronavirus 2
quercetin-3-O-rutinoside i.e. rutin, most active compared to all quercetin derivatives Severe acute respiratory syndrome coronavirus 2
quercetin-7-O-glucuronide better binding affinities than quercetin Severe acute respiratory syndrome coronavirus 2
quercetin-7-O-sulfate better binding affinities than quercetin Severe acute respiratory syndrome coronavirus 2
quercitrin strong binding affinity to the enzyme (RdRp) Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors diphosphate + RNAn+1
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 ?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
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 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
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 ?
nucleoside triphosphate + RNAn the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
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 ?

Synonyms

Synonyms Comment Organism
nsp12
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 Severe acute respiratory syndrome coronavirus 2
RDRP
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 Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
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 Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
physiological function the nsp12 (RdRp) is a central component of SARS-CoV-2 replication/transcription machinery. It catalyzes the synthesis of a complementary RNA strand using the virus RNA template with the assistance of nsp7 and nsp8 as cofactors Severe acute respiratory syndrome coronavirus 2