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Literature summary for 2.7.7.48 extracted from

  • Arba, M.; Wahyudi, S.T.; Brunt, D.J.; Paradis, N.; Wu, C.
    Mechanistic insight on the remdesivir binding to RNA-dependent RNA polymerase (RdRp) of SARS-cov-2 (2020), Comput. Biol. Med., 129, 104156 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
remdesivir
-
Severe acute respiratory syndrome coronavirus 2
remdesivir triphosphate using pharmacophore models, three natural product hits SN00166900, SN00303170 and SN00359915 are identified which have lower binding energies than that of remdesivir triphosphate Severe acute respiratory syndrome coronavirus 2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 diphosphate + RNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Severe acute respiratory syndrome coronavirus 2 P0DTD1 replicase polyprotein 1ab; SARS-CoV-2
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
?
nucleoside triphosphate + RNAn RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RDRP
-
Severe acute respiratory syndrome coronavirus 2
RNA-dependent RNA polymerase
-
Severe acute respiratory syndrome coronavirus 2

General Information

General Information Comment Organism
physiological function RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2