Inhibitors | Comment | Organism | Structure |
---|---|---|---|
remdesivir | - |
Severe acute respiratory syndrome coronavirus 2 | |
remdesivir triphosphate | using pharmacophore models, three natural product hits SN00166900, SN00303170 and SN00359915 are identified which have lower binding energies than that of remdesivir triphosphate | Severe acute respiratory syndrome coronavirus 2 |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | Severe acute respiratory syndrome coronavirus 2 | RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 | diphosphate + RNAn+1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Severe acute respiratory syndrome coronavirus 2 | P0DTD1 | replicase polyprotein 1ab; SARS-CoV-2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nucleoside triphosphate + RNAn | - |
Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? | |
nucleoside triphosphate + RNAn | RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 | diphosphate + RNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
RDRP | - |
Severe acute respiratory syndrome coronavirus 2 |
RNA-dependent RNA polymerase | - |
Severe acute respiratory syndrome coronavirus 2 |
General Information | Comment | Organism |
---|---|---|
physiological function | RNA-dependent RNA polymerase is a key enzyme which regulates the viral replication of SARS-CoV-2 | Severe acute respiratory syndrome coronavirus 2 |