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Literature summary for 2.7.7.48 extracted from

  • Wiegand, S.; Meier, D.; Seehafer, C.; Malicki, M.; Hofmann, P.; Schmith, A.; Winckler, T.; Foeldesi, B.; Boesler, B.; Nellen, W.; Reimegard, J.; Kaeller, M.; Haellman, J.; Emanuelsson, O.; Avesson, L.; Soederbom, F.; Hammann, C.
    The Dictyostelium discoideum RNA-dependent RNA polymerase RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for the spreading of RNA silencing signals (2014), Nucleic Acids Res., 42, 3330-3345.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene rrpC, DNA and amino acid sequence determination and analysis, quantitative real-time PCR expression analysis Dictyostelium discoideum

Protein Variants

Protein Variants Comment Organism
additional information rrpC gene knockout by gene disruption Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
nucleoside triphosphate + RNAn Dictyostelium discoideum
-
 diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn Dictyostelium discoideum AX2
-
 diphosphate + RNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum Q54UI6 gene rrpC
-
Dictyostelium discoideum AX2 Q54UI6 gene rrpC
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nucleoside triphosphate + RNAn
-
 Dictyostelium discoideum diphosphate + RNAn+1
-
 ?
nucleoside triphosphate + RNAn
-
 Dictyostelium discoideum AX2 diphosphate + RNAn+1
-
 ?

Synonyms

Synonyms Comment Organism
RNA-dependent RNA polymerase
-
 Dictyostelium discoideum
RrpC
-
 Dictyostelium discoideum

General Information

General Information Comment Organism
malfunction in deletion strains of the RNA-dependent RNA polymerase RrpC, full-length and shorter retrotransposable element DIRS-1 (Dictyostelium intermediate repeat sequence 1) messenger RNAs are strongly enriched, shorter versions of long non-coding RNA in DIRS-1 antisense orientation are also enriched in rrpC- strains. DIRS-1 misregulation in the absence of RrpC leads to retrotransposon mobilization Dictyostelium discoideum
physiological function the RNA-dependent RNA polymerase RrpC silences the centromeric retrotransposon DIRS-1 post-transcriptionally and is required for the spreading of RNA silencing signals. RrpC is a key player in the silencing of centromeric retrotransposon DIRS-1. RrpC acts at the post-transcriptional level and is involved in spreading of RNA silencing signals, both in the 5' and 3' directions Dictyostelium discoideum