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Literature summary for 2.7.7.48 extracted from

  • Wagner, S.D.; Yakovchuk, P.; Gilman, B.; Ponicsan, S.L.; Drullinger, L.F.; Kugel, J.F.; Goodrich, J.A.
    RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA (2013), EMBO J., 32, 781-790.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
alpha-Amanitin alpha-amanitin inhibits extension of B2 RNA by Pol II in vitro Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RNA polymerase II (PolII) acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. Pol II extends B2 RNA by 18 nt on its 3'-end in an internally templated reaction. The RNA product resulting from extension of B2 RNA by the Pol II RdRP can be removed from Pol II by a factor present in nuclear extracts ?
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nucleoside triphosphate + RNAn Homo sapiens B2 RNA is a substrate for RNA dependent RNA polymerization by Pol II diphosphate + RNAn+1
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNA polymerase II (PolII) acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. Pol II extends B2 RNA by 18 nt on its 3'-end in an internally templated reaction. The RNA product resulting from extension of B2 RNA by the Pol II RdRP can be removed from Pol II by a factor present in nuclear extracts Homo sapiens ?
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nucleoside triphosphate + RNAn B2 RNA is a substrate for RNA dependent RNA polymerization by Pol II Homo sapiens diphosphate + RNAn+1
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 ?
nucleoside triphosphate + RNAn B2 RNA is a substrate for RNA dependent RNA polymerization by Pol II. Extension of B2 RNA by Pol II occurs from the 3'-end and is internally templated and requires all four NTPs, mechanism, overview. No activity with B2 RNA mutated at C155 to G Homo sapiens diphosphate + RNAn+1
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 ?

Synonyms

Synonyms Comment Organism
RDRP
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 Homo sapiens
RNA-dependent RNA polymerase
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 Homo sapiens

General Information

General Information Comment Organism
additional information treatment of cells with a-amanitin or actinomycin D revealed that extension of B2 RNA by Pol II destabilizes the RNA Homo sapiens
physiological function RNA polymerase II acts as an RNA-dependent RNA polymerase to extend and destabilize a non-coding RNA. Mammalian Pol II acts as an RdRP to control the stability of a cellular RNA by extending its 3'-end. Extended B2 RNA can repress transcription, but with decreased potency Homo sapiens