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Literature summary for 2.7.7.48 extracted from

  • Carta, A.; Briguglio, I.; Piras, S.; Corona, P.; Boatto, G.; Nieddu, M.; Giunchedi, P.; Marongiu, M.E.; Giliberti, G.; Iuliano, F.; Blois, S.; Ibba, C.; Busonera, B.; La Colla, P.
    Quinoline tricyclic derivatives. Design, synthesis and evaluation of the antiviral activity of three new classes of RNA-dependent RNA polymerase inhibitors (2011), Bioorg. Med. Chem., 19, 7070-7084.
    View publication on PubMed
Search for more literature for 2.7.7.48

Inhibitors

Inhibitors Comment Organism Structure
1,3-bis-(4-chloro-1H(3H)-triazolo[4,5-g]quinoline)propan-2-one moderate antiproliferative activity for the cell lines tested Bovine viral diarrhea virus 1
3-benzyl-5-chloropyrido[3,2-g]quinoxalin-2(1H)-one moderate antiproliferative activity for the cell lines tested Bovine viral diarrhea virus 1
4-chloro-2-(4-nitrophenyl)-3H-imidazo[4,5-g]quinoline in addition, inhibitory to the recombinant hepacivirus enzyme. Compound shows no cytotoxicity for the various cell lines tested, exception made for HepG-2 cells Bovine viral diarrhea virus 1
4-chloro-2-(4-nitrophenyl)-3H-imidazo[4,5-g]quinoline in addition, inhibitory to the recombinant bovine viral diarrhea virus enzyme. Compound shows no cytotoxicity for the various cell lines tested, exception made for HepG-2 cells Hepacivirus C
5-chloro-3-phenylpyrido[3,2-g]quinoxalin-2(1H)-one compound is equally cytotoxic for all cell lines tested Bovine viral diarrhea virus 1

Organism

Organism UniProt Comment Textmining
Bovine viral diarrhea virus 1
-
-
-
Hepacivirus C
-
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00006
-
 pH 7.0, 22°C Bovine viral diarrhea virus 1 4-chloro-2-(4-nitrophenyl)-3H-imidazo[4,5-g]quinoline
0.0004
-
 pH 7.0, 22°C Bovine viral diarrhea virus 1 1,3-bis-(4-chloro-1H(3H)-triazolo[4,5-g]quinoline)propan-2-one
0.0008
-
 pH 7.0, 22°C Hepacivirus C 4-chloro-2-(4-nitrophenyl)-3H-imidazo[4,5-g]quinoline
0.001
-
 pH 7.0, 22°C Bovine viral diarrhea virus 1 5-chloro-3-phenylpyrido[3,2-g]quinoxalin-2(1H)-one
0.0012
-
 pH 7.0, 22°C Bovine viral diarrhea virus 1 3-benzyl-5-chloropyrido[3,2-g]quinoxalin-2(1H)-one