Literature summary for 2.7.7.48 extracted from

Cannon, N.A.; Donlin, M.J.; Mayes, L.M.; Lyra, A.C.; Di Bisceglie, A.M.; Tavis, J.E.
Evidence for action of ribavirin through the hepatitis C virus RNA polymerase (2009), J. Viral Hepat., 16, 595-604.

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Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis, sequence comparisons, NS5B genotyping, enzyme activities, and activity with ribavirin, overview. Expression of His-tagged enzyme variants in Escherichia coli	Hepacivirus C

Organism

Organism	UniProt	Comment	Textmining
Hepacivirus C	P26663	i.e. HCV	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant His-tagged enzyme variants from Escherichia coli by nickel affinity chromatography	Hepacivirus C

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Hepacivirus C	diphosphate + RNAn+1	-	?
ribavirin triphosphate + RNAn	ribavirin is a guanosine analogue that can be a substrate for the viral RNA polymerase. HCV is genetically variable, and this genetic variation can affect the polymerase's use of ribavirin triphosphate, overview	Hepacivirus C	?	-	?

Synonyms

Synonyms	Comment	Organism
NS5B	-	Hepacivirus C
RDRP	-	Hepacivirus C
RNA polymerase	-	Hepacivirus C

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Release 2023.1 (January 2023)